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Cyanide poisoning
Adult: To be given after 300 mg of sodium nitrite has been administered over 5-20 minutes: 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution) given over 10 minutes. If symptoms of cyanide toxicity recur, the dose may be repeated after 30 minutes at half the initial doses.
Child: To be given after 4-10 mg/kg of sodium nitrite (max: 300 mg) has been administered over 5-20 minutes: 400 mg/kg of sodium thiosulfate, as a 25 or 50% solution (max: 12.5 g). If symptoms of cyanide toxicity recur, the dose of nitrite and thiosulfate may be repeated after 30 minutes at half the initial doses.
Child: To be given after 4-10 mg/kg of sodium nitrite (max: 300 mg) has been administered over 5-20 minutes: 400 mg/kg of sodium thiosulfate, as a 25 or 50% solution (max: 12.5 g). If symptoms of cyanide toxicity recur, the dose of nitrite and thiosulfate may be repeated after 30 minutes at half the initial doses.
